Associations of DNA Methylation With Behavioral Problems, Gray Matter Volumes, and Negative Life Events Across Adolescence: Evidence From the Longitudinal IMAGEN Study

Publié le 31 janvier 2023 - Biological Psychiatry

Auteurs : Yan Sun, Tianye Jia, Edward Barker, Di Chen, Zuo Zhang, Jiayuan Xu, Suhua Chang, Guangdong Zhou, Yun Liu, Nicole Tay, Qiang Luo, Xiao Chang, Tobias Banaschewski, Arun Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane Fröhner, Michael Smolka, Henrik Walter, Robert Whelan, Lin Lu, Jie Shi, Gunter Schumann, Sylvane Desrivières, Arun L.W. Bokde

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Negative life events (NLEs) increase the risk for externalizing behaviors (EBs) and internalizing behaviors (IBs) in adolescence and adult psychopathology. DNA methylation associated with behavioral problems may reflect this risk and long-lasting effects of NLEs.