Pharmacology

Dépistage et prévention des neuropathies optiques toxiques aux anti-mycobactériens : proposition de recommandations

Publié le - Journal Français d'Ophtalmologie

Auteurs : C. Orssaud, D.T. Nguyen, C. Rouzaud, J. Pavie, J. Pinot, Olivier Lortholary, D. Bremond-Gignac, M.P. Robert

While treatment of pulmonary infections by Mycobacterium tuberculosis is currently only rarely the cause of iatrogenic complications, treatment of atypical mycobacterial infections often requires prolonged treatment duration, which can lead to toxic optic neuropathies. This review summarizes the indications for such prolonged treatment and risk factors for toxic optic neuropathies when using ethambutol, isoniazid and/or linezolid and proposes customized screening recommendations.