Late-onset and nonlate-onset schizophrenia: A comparison of clinical characteristics in a multicenter study

Publié le 31 décembre 2020 - International Journal of Geriatric Psychiatry

Auteurs : C. Passerieux, J. Pellerin, J. Perlbarg, S. Perron, A. Petit, F. Petitjean, C. Portefaix, D. Pringuey, A. Radtchenko, H. Rahiou, D. Raucher-Chene, A. Rauzy, L. Reinheimer, M. Renard, M. Rene, C. E. Rengade, P. Reynaud, D. Robin, C. Rodrigues, A. Rollet, F. Rondepierre, B. Rousselot, S. Rubingher, G. Saba, J. P. Salvarelli, J. C. Samuelian, C. Scemama-Ammar, F. Schurhoff, J. P. Schuster, D. Sechter, B. Segalas, T. Seguret, A. S. Seigneurie, A. Semmak, F. Slama, S. Taisne, M. Taleb, J. L. Terra, D. Thefenne, E. Tran, R. Tourtauchaux, M. N. Vacheron, V. Vanhoucke, E. Venet, H. Verdoux, A. Viala, G. Vidon, M. Vitre, J. L. Vurpas, C. Wagermez, M. Walter, X. Zendjidjian, Sandra Abou Kassm, Frederic Limosin, Wadih Naja, Pierre Vandel, Marina Sanchez-Rico, Jesus M. Alvarado, Armin Von Gunten, Nicolas Hoertel, J. Ades, C. Alezrah, I Amado, G. Amar, O. Andrei, D. Arbault, G. Archambault, G. Aurifeuille, S. Barriere, C. Bera-Potelle, Y. Blumenstock, H. Bardou, M. Bareil-Guerin, P. Barrau, C. Barrouillet, E. Baup, N. Bazin, B. Beaufils, J. Ben Ayed, M. Benoit, K. Benyacoub, T. Bichet, F. Blanadet, O. Blanc, J. Blanc-Comiti, D. Boussiron, A. M. Bouysse, A. Brochard, O. Brochart, B. Bucheron, M. Cabot, V Camus, J. M. Chabannes, V Charlot, T. Charpeaud, C. Clad-Mor, C. Combes, M. Comisu, B. Cordier, F. Costi, J. P. Courcelles, M. Creixell, H. Cuche, C. Cuervo-Lombard, A. Dammak, D. da Rin, J. B. Denis, H. Denizot, A. Deperthuis, E. Diers, S. Dirami, D. Donneau, P. Dreano, C. Dubertret, E. Duprat, D. Duthoit, C. Fernandez, P. Fonfrede, N. Freitas, P. Gasnier, J. Gauillard, F. Getten, Fabien Gierski, F. Godart, R. Gourevitch, Grassin A. Delyle, J. Gremion, H. Gres, V Griner, C. Guerin-Langlois, C. Guggiari, O. Guillin, H. Hadaoui, E. Haffen, S. Haouzir, C. Hanon, C. Hazif-Thomas, A. Heron, B. Hubsch, I Jalenques, D. Januel, A. Kaladjian, J. F. Karnycheff, O. Kebir, M. O. Krebs, C. Lajugie, M. Leboyer, P. Legrand, M. Lejoyeux, V Lemaire, E. Leroy, D. Levy-Chavagnat, A. Leydier, C. Liling, P. M. Llorca, P. Loeffel, P. Louville, Lucas S. Navarro, N. Mages, M. Mahi, O. Maillet, A. Manetti, C. Martelli, P. Martin, M. Masson, I Maurs-Ferrer, J. Mauvieux, S. Mazmanian, E. Mechin, L. Mekaoui, M. Meniai, A. Metton, A. Mihoubi, M. Miron, G. Mora, Niro Ades, P. Nubukpo, C. Omnes, S. Papin, P. Paris

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Objectives Data are scarce regarding the potential clinical differences between non-late onset schizophrenia (NLOS, i.e., disorder occurring before 40 years of age), late-onset schizophrenia (LOS, occurring between ages 40 and 60 years) and very-late-onset schizophrenia-like psychosis (VLOSLP, occurring after 60 years of age). Furthermore, previous research compared LOS patients with non-age matched NLOS patients. In this study, we sought to examine potential clinical differences between patients of similar age with LOS and NLOS. Methods/Design This is a cross-sectional multicentre study that recruited in- and outpatients older adults (aged >= 55 years) with an ICD-10 diagnosis of schizophrenia or schizoaffective disorder with NLOS and LOS. Sociodemographic and clinical characteristics, comorbidity, psychotropic medications, quality of life, functioning, and mental health care utilization were drawn for comparison. Results Two hundred seventy-two participants (79.8%) had NLOS, 61 (17.9%) LOS, and 8 (2.3%) VLOSLP. LOS was significantly and independently associated with greater severity of emotional withdrawal and lower severity of depression (all p