Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence

Publié le 31 août 2025 - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Auteurs : Lucy Vanes, Divyangana Rakesh, Tobias Banaschewski, Arun L W Bodke, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Herve Lemaitre, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N Smolka, Sarah Hohmann, Nathalie Holz, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Gareth J Barker, Michael Rapp, Marie-Laure Paillère Martinot, Sophia Schneider, Christine Bach, Tomas Paus, Alexis Barbot, Gareth J Barker, Arun Bokde, Nora Vetter, Christian Büchel, Anna Cattrell, Patrick Constant, Penny Gowland, Hans Crombag, Katharina Czech, Jeffrey Dalley, Benjamin Decideur, Tade Spranger, Tamzin Ripley, Nadja Heym, Herta Flor, Wolfgang Sommer, Birgit Fuchs, Jürgen Gallinat, Hugh Garavan, Rainer Spanagel, Mehri Kaviani, Bert Heinrichs, Andreas Heinz, Naresh Subramaniam, Tianye Jia, Albrecht Ihlenfeld, James Ireland, Bernd Ittermann, Patricia Conrod, Tobias Banaschewski, Jennifer Jones, Arno Klaassen, Christophe Lalanne, Dirk Lanzerath, Claire Lawrence, Hervé Lemaitre, Sylvane Desrivières, Catherine Mallik, Karl Mann, Adam Mar, Lourdes Martinez-Medina, Jean-Luc Martinot, Eva Mennigen, Fabiana Mesquita de Carvahlo, Yannick Schwartz, Ruediger Bruehl, Kathrin Müller, Frauke Nees, Charlotte Nymberg, Mark Lathrop, Trevor Robbins, Zdenka Pausova, Jani Pentilla, Francesca Biondo, Jean-Baptiste Poline, Sarah Hohmann, Luise Poustka, Sabina Millenet, Michael N Smolka, Juliane Fröhner, Maren Struve, Steve Williams, Thomas Hübner, Uli Bromberg, Semiha Aydin, John Rogers, Alexander Romanowski, Christine Schmäl, Dirk Schmidt, Stephan Ripke, Mercedes Arroyo, Florian Schubert, Yolanda Pena-Oliver, Mira Fauth-Bühler, Xavier Mignon, Robert Whelan, Claudia Speiser, Tahmine Fadai, Dai Stephens, Andreas Ströhle, Marie-Laure Paillere, Nicole Strache, David Theobald, Sarah Jurk, Helene Vulser, Ruben Miranda, Juliana Yacubilin, Vincent Frouin, Alexander Genauck, Caroline Parchetka, Isabel Gemmeke, Johann Kruschwitz, Katharina Weiß, Henrik Walter, Jianfeng Feng, Dimitri Papadopoulos, Irina Filippi, Alex Ing, Barbara Ruggeri, Bing Xu, Congying Chu, Eanna Hanratty, Erin Burke Quinlan, Gabriel Robert, Gunter Schumann, Tao Yu, Veronika Ziesch, Alicia Stedman, Christine Macare

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BACKGROUND: Adolescence is a critical period of neurodevelopment marked by ongoing maturation of structural and functional brain connectivity. Simultaneously, this period is associated with an increase in mental health problems, spanning from subclinical symptoms to diagnosable disorders. METHODS: This study investigated longitudinal associations between psychopathology dimensions and voxelwise brain measures related to connectivity across 3 time points (ages 14, 19, and 23) in more than 1500 participants using the IMAGEN dataset. White matter (WM) microstructure was indexed using diffusion metrics quantified along the WM skeleton (N = 1736), while functional connectivity was captured as voxelwise degree centrality (DC) derived from resting-state functional imaging (N = 1510). RESULTS: Development of WM microstructure was selectively linked to externalizing (but not internalizing) symptoms. Here, higher externalizing symptoms were associated with widespread reductions in fractional anisotropy (FA) across the WM skeleton as well as accelerated decreases in FA in the corticospinal tract over time. In contrast, functional DC was developmentally associated with general, rather than specific, psychopathology in frontal and temporal regions. An increase in total difficulties over time was associated with developmental decrease in DC in bilateral superior frontal gyri. In addition, a positive association between total difficulties and DC in left inferior temporal gyrus was observed in younger, but not older, adolescents or young adults. CONCLUSIONS: These findings highlight the dynamic interplay between brain connectivity development and psychopathology in adolescence, with potential implications for identifying neural markers of risk and resilience during sensitive windows of development.