Reward Versus Nonreward Sensitivity of the Medial Versus Lateral Orbitofrontal Cortex Relates to the Severity of Depressive Symptoms

Publié le 28 février 2021 - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

Auteurs : Chao Xie, Tianye Jia, Edmund Rolls, Trevor Robbins, Barbara Sahakian, Jie Zhang, Zhaowen Liu, Wei Cheng, Qiang Luo, Chun-Yi Zac Lo, He Wang, Tobias Banaschewski, Gareth Barker, Arun Bokde, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Sarah Hohmann, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane Fröhner, Juliane Fröhner, Michael Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jianfeng Feng, Arun L.W. Bokde, Eric Artiges, Semiha Aydin, Alexis Barbot, Andreas Becker, Pauline Bezivin-Frere, Francesca Biondo, Congying Chu, Patricia Conrod, Laura Daedelow, Jeffrey Dalley, Eoin Dooley, Irina Filippi, Ariane Fillmer, Vincent Frouin, Yvonne Grimmer, Albrecht Ihlenfeld, Alex Ing, Corinna Isensee, Hervé Lemaitre, Emma Lethbridge, Sabina Millenet, Sarah Miller, Ruben Miranda, Dimitri Papadopoulos, Zdenka Pausova, Jani Pentilla, Jean-Baptiste Poline, Erin Burke, Michael Rapp, Gabriel Robert, John Rogers, Barbara Ruggeri, Argyris Stringaris, Betteke van Noort, Roux Simon, Steve Williams, Yuning Zhang

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The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms.