Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study

Publié le 30 avril 2021 - Journal of the American Academy of Child and Adolescent Psychiatry

Auteurs : Iliyan Ivanov, Muhammad Parvaz, Eva Velthorst, Riaz Shaik, Sven Sandin, Gabriela Gan, Philip Spechler, Matthew Albaugh, Bader Chaarani, Scott Mackey, Tobias Banaschewski, Arun Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Herve Lemaitre, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane Fröhner, Michael Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan, Arun L.W. Bokde, Michael Rapp, Sophia Schneider, Alexis Barbot, Gareth Barker, Nora Vetter, Anna Cattrell, Patrick Constant, Hans Crombag, Jeffrey Dalley, Benjamin Decideur, Tade Spranger, Tamzin Ripley, Nadja Heym, Wolfgang Sommer, Birgit Fuchs, Jürgen Gallinat, Rainer Spanagel, Mehri Kaviani, Bert Heinrichs, Naresh Subramaniam, Tianye Jia, Albrecht Ihlenfeld, James Ireland, Patricia Conrod, Jennifer Jones, Arno Klaassen, Christophe Lalanne, Dirk Lanzerath, Claire Lawrence, Catherine Mallik, Karl Mann, Adam Mar, Lourdes Martinez-Medina, Eva Mennigen, Fabiana Mesquita de Carvahlo, Yannick Schwartz, Ruediger Bruehl, Kathrin Müller, Charlotte Nymberg, Mark Lathrop, Trevor Robbins, Zdenka Pausova, Jani Pentilla, Francesca Biondo, Jean-Baptiste Poline, Maren Struve, Steve Williams, Thomas Hübner, Semiha Aydin, John Rogers, Alexander Romanowski, Christine Schmäl, Dirk Schmidt, Stephan Ripke, Mercedes Arroyo, Florian Schubert, Yolanda Pena-Oliver, Mira Fauth-Bühler, Xavier Mignon, Claudia Speiser, Tahmine Fadai, Dai Stephens, Andreas Ströhle, Nicole Strache, David Theobald, Sarah Jurk, Helene Vulser, Ruben Miranda, Juliana Yacubilin, Vincent Frouin, Alexander Genauck, Caroline Parchetka, Isabel Gemmeke, Johann Kruschwitz, Katharina Weib, Jianfeng Feng, Dimitri Papadopoulos, Irina Filippi, Alex Ing, Barbara Ruggeri, Bing Xu, Christine Macare, Congying Chu, Eanna Hanratty, Erin Burke Quinlan, Gabriel Robert, Tao Yu, Veronika Ziesch, Alicia Stedman

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It is unclear whether deviations in brain and behavioral development, which may underpin elevated substance use during adolescence, are predispositions for or consequences of substance use initiation. Here, we examine behavioral and neuroimaging indices at early and mid-adolescence in drug-naive youths to identify possible predisposing factors for substance use initiation and its possible consequences.